The 15 hub genes that were identified as associated with AML progression in the present study were: BDP1, RFX7, LARP4, TCEGR1, MPHOSPH9, CCDC18, PDS5A, FANCL, and ICE2 in the turquoise module; and SERPINB7, CEACAM5, MUC2, RHOV, ALDH3A1, and CBLC in the blue module. This evidence concerns the gene CCDC18 and acute myeloid leukemia.