CIITA and glioblastoma: In hepatocarcinoma cells, that like GBM cells are normally HLA-II negative but can express similarly high level of HLA-II upon CIITA transfection, it has been shown that CIITA-transduced cells were capable of processing the exogenously loaded Mycobacterium tuberculosis Ag85 protein to present a specific epitope recognized by an HLA-DR-restricted epitope-specific T cell line (58).