For examples, tumor-associated antigens such as Chondroitin sulfate proteoglycan 4 (CSPG4) and Tenascin (TNC), also known as Glioma-associated-extracellular matrix antigen, were found only in the GBM cells, while Transferrin receptor protein 1 (TRFC) that is a mediator of iron uptake necessary for, and positively regulates, T and B cell proliferation was highly presented in T and B cells. The gene discussed is TFRC; the disease is glioma.