This is particularly important in pancreatic cancer, where activation of the myofibroblast-like stellate cells and consequent fibrosis are the major contributors to the highly aggressive nature of these tumors and poor treatment efficacy.21, 22, 23 Although some exosomal components are known to contribute to fibroblast activation and recruitment (e.g., TGF-β and Lin28B),19,24 the pathways responsible for alterations in their packaging and secretion in cancer cells remain largely unknown. Here, TGFB1 is linked to cancer.