Nevertheless, the heterogeneous frequency of NPM1 mutations among FLT3-like leukemias, and particularly its low frequency in pediatric AML, along with the reproducibility of the FLT3-like pattern in all cohorts, indicate that co-occurring NPM1 mutations are insufficient to explain the existence of the FLT3-like pattern. This evidence concerns the gene FLT3 and acute myeloid leukemia.