Nevertheless, the heterogeneous frequency of NPM1 mutations among FLT3-like leukemias, and particularly its low frequency in pediatric AML, along with the reproducibility of the FLT3-like pattern in all cohorts, indicate that co-occurring NPM1 mutations are insufficient to explain the existence of the FLT3-like pattern. The gene discussed is NPM1; the disease is acute myeloid leukemia.