DHEAS level was found to be inversely correlated with age in years (r = 0.241, p = 0.03) (Fig 2).The correlation was weak (spearman rho coefficient of correlation = -0.241) but statistically significant (p = 0.03).There was no statistically significant correlation of Anti TPO Ab (r = -0.12, p = 0.69), vitamin D (r = 0.11, p = 0.61), RA factor (r = 0.4, p = 0.051), hsCRP (r = 0.46, p = 0.53) with EULAR-CSA (Table 2) On multiple regression analysis, serum DHEAS predicted rheumatism as defined by EULAR CSA score, F(1,11.5) = 4.09, p = 0.049. The gene discussed is TPO; the disease is rheumatic disorder.