Total-CORT levels in the hippocampus did not change as a consequence of CBG deficiency (20.34 ± 2.62 vs. 22.31 ± 2.28 ng CORT/g protein in cbg+/+ and cbg-/- mice respectively, P = 0.512), but the free-CORT levels were slightly elevated in cbg-/- mice compared to those in cbg+/+ mice (20.90 ± 3.11 vs. 12.61 ± 3.45 ng CORT/g protein respectively, P = 0.047) (Fig 1B). This evidence concerns the gene SERPINA6 and hyperinsulinemic hypoglycemia, familial, 4.