No differences in Tau mRNA or total protein levels were found between cbg+/+ and cbg-/- mice; however, CBG deficiency was associated with a significant increase in the phosphorylation of Tau protein at residues serine-202 and threonine-205, both of which were detected by the anti-AT8 antibody (Fig 4A). Here, MAPT is linked to hyperinsulinemic hypoglycemia, familial, 4.