It has been suggested that the cognitive impairment associated with type 2 diabetes may involve CORT [13, 14], and CORT hypersecretion has been reported in Alzheimer’s disease [15, 16] with the speed of cognitive decline being linked to increases in both blood and central nervous system CORT levels at the pre-dementia clinical stage [17, 18]. Here, CORT is linked to early-onset autosomal dominant Alzheimer disease.