Moreover, 18 genes (EIF4A3, RAN, PSMA3, CCNA2, POLR2D, CDC27, PGAM1, RACGAP1, PIP5K1B, DHX16, EP400, RNF2, PSMD7, CNOT1, SOX1, TADA2A, TNNI3, KMT2D) that scored as hits in cancer cell screens had least hazard than any other group of genes (Fig 3B) and better survival (Bin1 vs Bin7) at FDR threshold of 10% (Fig 3C). The gene discussed is RAN; the disease is cancer.