Also, since pRb is involved in numerous cancer hallmark pathways [29], besides G1/S transition/cell cycle control, such as metabolism, mitochondrial function, apoptosis, epigenetic state, and differentiation [3], our sensitized Rbf1 eye screen aimed at identifying a broad spectrum of Rbf1 genetic interactors using either overproliferation phenotypes, cell death phenotypes associated with activation of the cell cycle, or a diverse set of cell cycle-independent phenotypes. The gene discussed is RB1; the disease is cancer.