Interestingly, when Oser et al. re-expressed RB1 in RB1-deficient NCI-H82 SCLC cancer cell line and performed a CRISPR/Cas9 pRB SL screen [17], they also identified Ran, SNRPF, multiple POLR members and U2AF1. This evidence concerns the gene U2AF1 and small cell lung carcinoma.