Consistently, hematoxylin and eosin (H&E) staining also showed visible cytoplasmic fat vacuoles in the livers of the Lzp-/- mice fed a CHD, which were even more noticeable in the livers of the Lzp-/- mice fed a HFD (Fig 1I, left panel). Here, OIT3 is linked to coronary artery disorder.