EXT1 and cancer: These genes include PLAG1, CHCHD7, SOX17, TCEA1, NCOA2, TCEB1, HEY1, RUNX1T1, NBN, CNBD1, COX6C, UBR5, RAD21, EXT1, MYC, NDRG1, EPPK1 and RECQL4. Among these, MYC (8q24) has been studied in a variety of cancers and is known to be a cell cycle regulator, important for neoplastic transformation (36).