Meanwhile, TMEM106C was also found to be negatively associated with ZC3H13 (zinc finger CCCH-type containing 13) [27] (Pearson correlation = -2.7, P = 1.9E-10), DLC1 (deleted in liver cancer-1) [28, 29] (Pearson correlation = -1.8, P = 2.1E-05), and RANBP3L (RAN binding protein 3 like) [30] (Pearson correlation = -2.60, P = 1.1E-9) (Figure 4H–4J), which have been reported to mediate RNA N6-methyladenosine (m6A) methylation, suppress cancer metastasis, terminate BMP signaling and regulate mesenchymal stem cell differentiation, respectively. The gene discussed is TMEM106C; the disease is cancer.