To identify the hub genes, Kaplan-Meier method was performed to plot the survival curves of genes enriched in PI3K/Akt pathway for the assessment of prognostic significance and three genes (ITGB1, ITGB5, and OSMR) were observed to be significantly associated with prognosis of PAAD patients. This evidence concerns the gene ITGB5 and pancreatic adenocarcinoma.