To test this hypothesis and specifically elucidate the role of CysLT1R during AD pathogenesis, we downregulated the expression levels of CysLT1R by knockout or knockdown of the CysLT1R gene in APP/PS1 mice for the first time, and examined the effects of CysLT1R manipulation on amyloidosis, synaptic plasticity, cognition, neuroinflammation, and KP regulation. This evidence concerns the gene NPPA and Alzheimer disease.