RETREG1 and infection: Second, our observation ofFAM134B-RHD-induced membrane budding explains the “membraneshredding” action of FAM134B-RHD, which results in the formationof tiny vesicular structures.5,7 Highlighting the biologicalrelevance of FAM134B-RHD in ER-phagy, we note that Zika and Dengueviruses proteolytically target FAM134B-RHD to evade host responsesduring infection.18