LMO2 forms a transcriptional complex that regulates gene expression in DLBCL and is usually overregulated in NHL and is associated with improved prognosis in both DLBCL and PCNSL, being overexpressed in 52% of PCNSL (Cubedo et al., 2012; Lossos et al., 2014). Here, LMO2 is linked to primary central nervous system lymphoma.