In ob/ob mice, insulin resistance was accompanied by the SERCA injury and ER stress in the liver,37 while the CDN1163, which is a novel allosteric SERCA2 modulator, could decrease blood glucose and fasting insulin levels, resulting in improved glucose tolerance in ob/ob mice even in the absence of reduction in food intake, these results indicating the important role of SERCA in metabolic disorders. This evidence concerns the gene INS and Other metabolic disease.