We found that long‐term HFD significantly facilitated the gene and protein expressions of pyroptosis markers including NLRP3, GSDMD/−N, caspase‐1, p20, IL‐1β and IL‐18, suggesting that pyroptosis is an important pathological process of NAFLD (Figure 8E,F). Here, GSDMD is linked to metabolic dysfunction-associated steatotic liver disease.