In ob/ob mice, insulin resistance was accompanied by the SERCA injury and ER stress in the liver,37 while the CDN1163, which is a novel allosteric SERCA2 modulator, could decrease blood glucose and fasting insulin levels, resulting in improved glucose tolerance in ob/ob mice even in the absence of reduction in food intake, these results indicating the important role of SERCA in metabolic disorders. This evidence concerns the gene INS and metabolic disease.