Neither the recently reported DPP6 variants [2] nor any other rare variants found in our study would confer risk to AD in European Americans, despite our cohorts (FASe, EOAD, and ADSP) were larger than that of [2] (CA = 558 and CO = 775), and we had enough statistical power (96.4%, α = 0.05, MAF = 0.01, OR = 2.00) to replicate their findings. The gene discussed is DPP6; the disease is Alzheimer disease.