Furthermore, we observed pronounced changes in the thermal stability of structural components of desmosomes which are involved in cell–cell adhesion; desmoplakin (DSP) was thermally destabilized between 7 and 24 h of infection while desmoglein‐2 (DSG2) and plakophilin‐2 (PKP2) showed thermal stabilization towards later time points (Fig 3A, and Dataset EV1). Here, DSG2 is linked to infection.