FFAR2 and colitis: Formation of inflammasomes leads to downstream production of IL-18, a key cytokine for the repair and maintenance of the epithelial integrity.49 However, in the context of colitis, ambivalent results have been published, which presents a possible dual role of SCFAs and GPCR43 in controlling inflammation.50 This explains the importance of cell types and their location for the downstream activation of GPR43.