FFAR2 and colorectal cancer: Deficiency of IL-10 in human and animal models leads to intestinal inflammation and the growth of enteric pathogens which can promote the development of colorectal cancer.46 GPCR43 is present in different tissues such as adipose tissue and gastrointestinal cells, with the highest expression found in immune cells.48 Recent evidence indicates that a high-fiber diet activates GPCR43 on IECs, which results in activation and assembly of the inflammasome, a protein complex that enables maturation of the pro-inflammatory cytokines by caspase-1-mediated cleavage.