TGFB1 and ovarian carcinoma: Other mechanisms include ubiquitination mechanisms that also depend on Type I receptor interactions with tumor necrosis factor receptor-associated factor 6 (TRAF6) and the subsequent activation of the MAPKKK TAK1 upstream activator of JNK and p38 [135, 136] which is required for TGFβ-induced EMT, in non-ovarian cancers [128, 137].