In this environment tumor cells have been shown to interact with the PMCs via TGFβ signaling, wherein cancer cell derived TGFβ1, via TGFβ1 receptor interactions on the PMCs’ activates a RAC1/SMAD pathway, leading to increased fibronectin expression and a mesenchymal phenotype in the PMCs [181]. Here, TGFB1 is linked to neoplasm.