The fact that Iso and Ang II-dependent CaMKII activation shifts HDAC4 in opposite directions, but downregulation of β-AR in HF coupled to upregulation of CaMKII signaling in heart failure may limit the MEF2 repressive effect of PKA and allow the CaMKII-dependent nuclear export to become more dominant. The gene discussed is CAMK2G; the disease is hydrops fetalis.