After adjustments for age, sex, education and established T2D risk factors, higher concentrations of Mn, Zn, I, Se, and SELENOP were associated with a higher risk of developing T2D (HR Q5 vs Q1, 95% CI 1.54, 1.10–2.17 for Mn; HR per SD, 95% CI 1.24, 1.12–1.38 for Zn; 1.11, 1.03–1.20 for I; 1.26, 1.12–1.41 for Se; 1.14, 1.02–1.29 for SELENOP) (Fig. 2). This evidence concerns the gene SELENOP and type 2 diabetes mellitus.