SIRT1 and optic nerve disorder: With a body of literature demonstrating that treatment with small molecular activators of the SIRT1 pathway, such as resveratrol, preserves visual function and RGC survival in mouse models of optic neuritis and optic nerve trauma [4–7, 17, 21, 24], the current results suggest that the AAV2.7m8-SIRT1 vector might have utility in multiple optic neuropathies.