HOXB13 and posterior cortical atrophy: Recent findings point to genetic factors that underlie familial aggregations of PCa; genetic differences between patients with and without family history of PCa can be based on single-nucleotide polymorphisms or germline mutations, including HOXB13, BRCA1, BRCA2, and MLH1, which are associated with an increased risk of familial PCa [7–11].