Antidepressant actions of compounds acting on other mGluR’s, more specifically in groups II and III, have also been elucidated; the mGluR2/3 NAM Ro449153 exhibited promise in preclinical settings and another mGluR2/3 NAM BCI-632 displayed antidepressant effects in rodent models and has been evaluated by an RCT for MDD treatment [151]. The gene discussed is GRM2; the disease is major depressive disorder.