Of the remaining 28 articles, 17 ones were excluded for the following reasons: six studies were performed for the association between -308G/A polymorphism of TNF-α gene and the components of MS, three studies did not have healthy controls, three studies were for other polymorphism sties of TNF-α gene, two studies were for other disorders, one study with repeating data, one study was meta-analysis, one study with wrong data. Here, TNF is linked to myeloid sarcoma.