All of the 102 fetuses with α-thalassemia major presented with Hb Barts (86.02 ± 3.79) and Hb Portland (11.67 ± 3.0), and 39 cases presented with Hb Epsilon4 (1.55 ± 0.21) and Hb Gower1 (4.20 ± 2.15) simultaneously. This evidence concerns the gene GSTM1 and thalassemia.