Among GWAS genes that interacted the most with depression portrait genes were the histone acetyltransferase, EP300, the Rho GTPase, RHOA, the heat shock protein HSPA1A, the dopamine receptor, DRD2, the glutamate receptor, GRM5, the huntington gene, HTT, and the estrogen receptor, ESR2. The gene discussed is ESR2; the disease is depressive symptom measurement.