Among GWAS genes that interacted the most with depression portrait genes were the histone acetyltransferase, EP300, the Rho GTPase, RHOA, the heat shock protein HSPA1A, the dopamine receptor, DRD2, the glutamate receptor, GRM5, the huntington gene, HTT, and the estrogen receptor, ESR2. Here, ESR2 is linked to major depressive disorder.