AHR and necrotizing enterocolitis: Importantly, I3C supplementation significantly reduced the severity of NEC in wild-type mice (Fig. 3a, c–e) but had a relatively little protective effect in either AhrΔIEC or Ahr-/- mice (Fig. 3a, c–e), confirming that AHR activation in the intestinal epithelium by I3C is required for protection against NEC.