Interestingly, the signature of SARS-CoV-2 infection (indicated by arrows) was aligned across both A549 and A549-ACE2 cells as well as across different levels of infection (MOI of 0.2 and 2), suggesting that the SARS-CoV-2 transcriptional signature was captured robustly by the L1000 genes, thus providing further rationale for using CMap to identify drugs that could reverse the effect of SARS-CoV-2 infection. The gene discussed is ACE2; the disease is infection.