We have previously shown that Nr2f6 expression in CD8+ T cells increases following T-cell receptor (TCR) stimulation and acts as a transcriptional repressor that protects against excessive and potentially harmful cytokine secretion during the effector phase19,21, Interestingly, in a setting with lymphocytic choriomeningitis virus (LCMV), during the acute phase of the infection Tem expressed higher levels of Nr2f6 when comparing to Tcm, whereas 180 days post infection the pattern was reversed (unpublished observations of the Immgen publicly available dataset). Here, CD8A is linked to infection.