Importantly, the differences between isotype and IFN-γ blocked CD127−KLRG1+ and CD127+KLRG1−Nr2f6-deficient OT-I T cells in the spleen persisted up to >d60 after infection (Fig. 6D), similar to the d70 phenotype of germ-line Nr2f6-deficient mice (Fig. 1). The gene discussed is IFNG; the disease is infection.