The fraction of cells carrying the exhaustion markers Lag-3, Tim-3, or PD-1 was comparable between Nr2f6+/+ and Nr2f6−/− CD8+OVAtet+ T cells, indicating that Nr2f6−/− cells do not become excessively exhausted (Fig. S1C)26, which is in contrasting our previous observations in tumor-infiltrating T cells19. This evidence concerns the gene LAG3 and neoplasm.