Also, prostate cancer development was shown to be mediated by the great alterations of signaling cascades including mutations in tumor-suppressor genes and oncogenes, cyclin-dependent kinase inhibitor-mediated cell cycle progression, the phosphatidylinositol 3-kinase/AKT (protein kinase B) pathway, and so on1,3–5. The gene discussed is AKT1; the disease is Familial prostate cancer.