We clearly demonstrated here that the SChLAP1-shRNA repressed prostate cancer cell proliferation, migration, and tumorigenic capacities in nude mice, which was consistent with previous reports showing the oncogenic roles of SChLAP1 in prostate cancer pathogenesis27,28, although it has been suggested that the oncogenic functions of SChLAP1 was mediated by its modulation of the SWI/SNF complex and resultant chromatin remodeling28. Here, SMARCA1 is linked to Familial prostate cancer.