DNMT3A and neoplasm: Moreover, the expression of DNMT3a mRNA and protein in tumor tissues was greatly repressed by SChLAP1 silencing, which resulted from great increases of miR-340-5p, miR-143-3p, and miR-145-5p expression in tumor tissues isolated from nude mice injected with SChLAP1-shRNA DU145 cells (Fig. 7D), whereas DNMT3a overexpression abrogated the above molecular alterations induced by SChLAP1 silencing in tumor tissues (Fig. 7D).