We observed that both GSK343 and γ-Oryzanol promoted miR-340-5p, miR-145-5p, and miR-143-3p expression in prostate cancer cells, showing the regulation of miR-340-5p, miR-145-5p and miR-143-3p expression by EZH2 and DNMT3a (Fig. 3A, B and Supplemental Fig. 1A). The gene discussed is DNMT3A; the disease is Familial prostate cancer.