CSCs activate the Notch pathway to promote of resistance to chemotherapy212 and radiation.213 Inhibiting Notch signaling could sensitize CSCs to cisplatin or carboplatin214 and radiation therapy.213 Nanog regulated Notch signaling along with ALDH activity and radiotherapy resistance in breast cancer.68 Moreover, crosstalk between Notch and NF-κB contributed to therapy resistance in triple-negative breast cancer (TNBC):215 Jagged1 triggers nuclear, NF-κB-dependent transcription of antiapoptotic gene cIAP-2. The gene discussed is NFKB1; the disease is triple-negative breast carcinoma.