CD44 and cancer: Moreover, CD44 expression suppressed ferroptosis in cancer cells, which indicated a correlation between CSCs and ferroptosis.174 Inhibition of autophagy increased the susceptibility of glioblastoma SCs to temozolomide by initiating ferroptosis.175 Furthermore, inducing ferroptosis could sensitize CSCs to chemotherapy in OC.176 In addition, as we mentioned before, salinomycin is a selective agent against CSCs and triggers ferritin degradation and ROS-mediated ferroptosis in CSCs,177 which may reverse the radiotherapy resistance caused by low ROS levels and enhanced DNA repair in CSCs.