NANOG and cancer: In 2010, the expression of Nanog was directly correlated with CSCs (CD133high/CD44high),66 and Nanog+ NSCLC cells were shown to exihibit CSC properties.58 Furthermore, the status of Nanog determines the switch between cancer cells and CSCs.67 Moreover, Nanog expression was associated with enhanced ALDH activity and cellular radioresistance68 and chemoreistance.69