FZD7 and tongue squamous cell carcinoma: SOX8 bound to the promoter region of Frizzled 7 (FZD7) and mediated EMT processes in chemoresistant tongue squamous cell carcinoma (TSCC) via the FZD7/Wnt/β-catenin pathway.140 Moreover, extracellular matrix 1 (ECM1) regulated Wnt-mediated EMT by increasing the association between β-catenin and MUC1 cytoplasmic tail.141 Twist1 is a basic helix-loop-helix transcription factor that potently drives the EMT process.