REST and neuroblastoma: In this work, we used two in vitro models i.e., murine neuroblastoma cells (N2a) and mouse primary neurons, which were challenged with either the supernatant of inflammatory activated T cells49–51 and microglia or with specific pro-inflammatory cytokines, to investigate the changes in expression and activity of REST and its splice isoform REST4 under inflammatory conditions and the cellular mechanisms leading to such changes.