After comprehensive analysis, we identified a novel circular RNA, hsa_circ_103820 (hsa_circ_0072309), which is located at chr5:38523520–38530768 (human GRCh37/hg19) and is encoded by leukemia inhibitory factor receptor (LIFR) gene exons that was significantly underexpressed in lung cancer compared to normal controls. The gene discussed is LIFR; the disease is lung carcinoma.