In addition, knockdown and overexpression of hsa_circ_103820 were conducted to determine the functions of hsa_circ_103820 in lung cancer cell lines, and we found that hsa_circ_103820 suppressed the proliferation, invasion, and migration of lung cancer cells by sponging miR-200b-3p and releasing its target genes large tumor suppressor kinase 2 (LATS2) and suppressor of cytokine signaling 6 (SOCS6). Here, LATS2 is linked to lung cancer.