To clarify whether SRC-3 abundance or LLPS was correlated with MM drug resistance, we expressed ectopic SRC-3 full length (FL) or SRC-3 ΔIDR in OPM-2 and LP-1 cells with endogenous SRC-3 depletion and found that only the FL SRC-3 rescued the resistance to BTZ treatment (Fig. 5k, Fig. S6i). The gene discussed is CASC3; the disease is Miyoshi myopathy.