This RNA-seq analysis revealed that an ample number of genes were significantly upregulated in BR-MM cells, including anti-apoptotic genes such as ATP-binding cassette transporters (ABC transporters), BCL2, and CCL4, as well as direct SRC-3-downstream targets, such as CBS, TNC, EGR1, and IGF1R (Fig. 6g, S Data 2). This evidence concerns the gene IGF1R and Miyoshi myopathy.