CD4 and neoplasm: By investigating the regulation of immune cell populations, we made two major observations: (1) The high-risk group had more complex immune cell components than the low-risk group, including cells exhibiting anti-tumor reactivity, such as activated CD4 T cells, activated dendritic cells, central memory CD4 T cells, central memory CD8 T cells, natural killer cells, and natural killer T cells, and cells with tumor suppression activity, such as immature dendritic cells, MDSCs, plasmacytoid dendritic cells, regulatory T cells, and type 2 T helper cells.