Our study found that the GPS, mGPS, Hs-mGPS, NLR, PLR, PNI, SII, and LCR scores were related to OS in univariate analysis, but only the LCR score (with the combination of lymphocytes and CRP, which are simple and objective but discriminatory in assessing high-risk HCC patients who underwent TACE) was the only independent predictor in the assessment of long-term survival in multivariate analysis. The gene discussed is CRP; the disease is hepatocellular carcinoma.