PDCD1 and neoplasm: Strikingly, the antitumoral effects observed in the LLC-OVA model were even further enhanced in the MC38 model, where Nb-Fc1B monotherapy resulted in complete tumor rejection in 2 out of 10 mice and the combination of Nb-Fc1B and anti-PD-1 therapy resulted in complete tumor rejection in all mice after therapy ceased (figure 7A–C).