CCR8 and neoplasm: First, we applied the SCENIC pipeline on the LLC-OVA tumor-infiltrating T/NKT cells to identify the master regulators that drive Ccr8 expression in the distinct T-cell subsets.41 This allowed us to identify key regulons within each T-cell population, after which the cells were re-clustered based on their regulon activity and were colored by their matching Seurat clusters (online supplemental figure S3A).