MSLN and ovarian carcinoma: In this case, we demonstrated that CAR-T cells targeting MSLN with the ability to secrete PD-1 antibodies with concomitant use of apatinib in chemotherapy-refractory ovarian cancer improve the treatment outcome and prolong PFS, possibly attributed to the synergetic effects of CAR-T cells, PD-1 antibody and antiangiogenesis.