Several recent clinical trials indicated that SGLT2 inhibition is an effective strategy for diabetes mellitus and concluded that it (1) facilitates reduction of body weight and visceral fat, (2) prevents progressive kidney disease, and (3) improves liver function in non-alcoholic steatohepatitis (NASH) occurring with diabetes mellitus. Here, SLC5A2 is linked to metabolic dysfunction-associated steatohepatitis.