Novel immunotherapeutic approaches targeting the tumor-associated antigen (TAA) mesothelin (MSLN) are currently being tested in clinical trials and have the potential to improve survival rates and prognosis in MM [5, 6], especially anti-MSLN Chimeric Antigen Receptor (CAR) T cell therapy, which is the focus of this review. The gene discussed is MSLN; the disease is Miyoshi myopathy.