Besides, we found that hypoxic treatment decreased the expression of LATS2 (Fig. S9b) and reduced 5’tiRNA-His-GTG inhibition-mediated suppressive effects on CRC cells (Fig. S10a), and 5’tiRNA-His-GTG inhibitor attenuated hypoxia-induced YAP activation (Fig. S10b), indicating a close relationship between 5’tiRNA-His-GTG and LATS2 under hypoxia. This evidence concerns the gene LATS2 and colorectal carcinoma.