Since MFGE8 was not upregulated in celecoxib-resistant TNBC cells, the potential synergistic effects of MFGE8 deletion with COX-2 inhibition on suppressing TNBC primary tumor growth might be due to convergent anti-angiogenesis pathway rather than overcoming celecoxib resistance and should be investigated in future studies. This evidence concerns the gene MFGE8 and neoplasm.