Based on the above gene selection criteria, we next cross-referenced all gene lists (GL1-GL6) and found 10 overlapping genes (TPM4, RGS2, LAMC2, SERPINB5, KLK7, MFGE8, KLK5, ID4, RBP1, SLC2A1) that show gene alteration/amplification in TNBCs, are highly expressed in aggressive BCs and COX-2 inhibitor-LS BC cell lines, and are associated with poor BC patient outcomes. The gene discussed is KLK5; the disease is breast cancer.