NSD3 and head and neck squamous cell carcinoma: The results of our multivariate analysis revealed that the HRs for NSD1 (low vs high expression) and NSD3 (low vs high expression and low vs mid expression) remained significant (HR = 32.88, 95% confidence interval (CI) = 3.23–333.33, p = 0.003; HR = 103.1, 95% CI = 8.55–1.24e03, p = 0.0003; HR = 135.3, 95% CI = 6.62–2.76e03, p = 0.001, respectively), indicating that low expression of NSD1 and NSD3 is a significant, and potentially independent, contributor to overall survival in the HPV+ HNSCC cohort.