Despite confirming a weak correlation between NSD1 RNA expression and TIL signature in HPV- HNSCC (Fig. 4b), and confirming that the TIL signature is generally higher in HPV+ HNSCC compared to both HPV- HNSCC and normal control tissues (Fig. 3), no significant correlation was observed for NSD1, NSD2, or NSD3 in HPV+ HNSCC (Fig. 4a). The gene discussed is NSD3; the disease is head and neck squamous cell carcinoma.