The KEGG pathway analysis revealed that the DEGs were primarily enriched in pathways related to cytokine − cytokine receptor interaction (19 genes, such as CXCL2, TNFRSF13, CD27), TCR signaling pathway (14 genes, such as ZAP70, CD8A), and Primary immunodeficiency (10 genes, such as ZAP70, TNFRSF13B) (Fig. 2b). This evidence concerns the gene CD27 and inborn error of immunity.