Functional analyses revealed that the overexpression of LINC00342 partly overturned the tumor suppressive effects of NPEPL1 knockdown in CRC, indicating that LINC00342 accelerated CRC progression, at least in part, through regulating the expression of NPEPL1 by serving as a sponge of miR-19a-3p. Here, NPEPL1 is linked to neoplasm.