As for UTUC, a higher frequency of genetic alteration, including in TP53, LRP1B, KMT2D, FAT4, BRCA1, FGFR2 and BRIPI, were found in our cohort of 31 cases compared with the MSKCC cohort (Fig. 2b). This evidence concerns the gene KMT2D and renal pelvis/ureter urothelial carcinoma.