As for UTUC, a higher frequency of genetic alteration, including in TP53, LRP1B, KMT2D, FAT4, BRCA1, FGFR2 and BRIPI, were found in our cohort of 31 cases compared with the MSKCC cohort (Fig. 2b). The gene discussed is TP53; the disease is renal pelvis/ureter urothelial carcinoma.