Considering that pan-cytokeratin staining is found in > 20% of seminomas and in > 80% of non-seminomas (summarized in (Emerson and Ulbright (2005))), the use of cytokeratin 18 showing positivity in 2.5% of seminomas and 100% of embryonal carcinoma of the testis as well as 100% of yolk sack tumors in our study might be preferable for testicular cancer subtyping. The gene discussed is KRT18; the disease is testicular embryonal carcinoma.