F10 and atrial fibrillation: Therefore, the aims of this secondary analysis from the ENGAGE AF-TIMI 48 trial (Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48) were to compare (1) the risk of cardiovascular events, (2) the differences of pharmacokinetic and pharmacodynamic properties of edoxaban (using a direct measure of the functional activity of endogenous FX in plasma) and warfarin, and (3) the efficacy and safety of edoxaban and warfarin in women versus men with AF and a CHADS2 score ≥2.