PLWH with COVID-19 were significantly more likely to have co-morbidities (63 vs. 38%, P = 0.00059), and had higher median BMI (25.5 vs. 23.7 kg/m2, P = 0.021) compared with 1288 PLWH without COVID-19. No association between CD4+ T cell count and SARS-CoV-2 infection or adverse COVID-19 outcomes. The gene discussed is CD4; the disease is COVID-19.